2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

Alkylator/Crosslinker

DNA Alkylator/Crosslinker

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DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W004702
    Methyl methanesulfonate
    		99.97%
    Methyl methanesulfonate is an alkylating agent which transfers methyl groups, and induces DNA damage. Methyl methanesulfonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Methyl methanesulfonate
  • HY-13585
    Carmustine
    		99.91%
    Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
    Carmustine
  • HY-101161
    SG3199
    		98.94%
    SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249).
    SG3199
  • HY-13669
    Lomustine
    		99.90%
    Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.
    Lomustine
  • HY-13733
    Procarbazine Hydrochloride
    		99.66%
    Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research.
    Procarbazine Hydrochloride
  • HY-129241
    AGX51
    		Antagonist 99.33%
    AGX51 is the first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and viability reduction. AGX51 can inhibit TNBC and has an IC50 of about 25 nM. AGX51 can be used in cancer research.
    AGX51
  • HY-128915
    Duocarmycin DM free base
    		99.69%
    Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.
    Duocarmycin DM free base
  • HY-13424
    RITA
    		98.77%
    RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.
    RITA
  • HY-17574
    Thio-TEPA
    		99.49%
    Thio-TEPA is a DNA alkylating agent, with antitumor activity.
    Thio-TEPA
  • HY-131031
    KCC-07
    		99.95%
    KCC-07 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity.
    KCC-07
  • HY-B0077
    Bendamustine hydrochloride
    		99.89%
    Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties.
    Bendamustine hydrochloride
  • HY-14573
    SJG-136
    		99.47%
    SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.
    SJG-136
  • HY-14798
    Palifosfamide
    		99.11%
    Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity.
    Palifosfamide
  • HY-105019A
    Melflufen hydrochloride
    		98.73%
    Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells.
    Melflufen hydrochloride
  • HY-13567
    Bendamustine
    		99.54%
    Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties.
    Bendamustine
  • HY-B1157
    Trioxsalen
    		99.49%
    Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation.
    Trioxsalen
  • HY-107769
    Duocarmycin TM
    		98.04%
    Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.
    Duocarmycin TM
  • HY-B0181
    Altretamine
    		99.91%
    Altretamine is an alkylating antineoplastic agent.
    Altretamine
  • HY-16513
    VAL-083
    		≥98.0%
    VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
    VAL-083
  • HY-101160
    SG2057
    		99.93%
    SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent.
    SG2057
Cat. No. Product Name / Synonyms Application Reactivity